Laboratory of Transcriptional and Immune Regulation
Harvard Institutes of Medicine
77 Avenue Louis Pasteur
Center for Neurologic Diseases, Room 614
Boston, MA 02115
 |
Principal Investigator: Fernando Dangond, M.D. |
Current Post-doctoral fellows
 |
 |
Sandra Camelo, M.D. (617) 525-5519 |
Antonio Iglesias, M.D. (617) 525-5518 |
Past Lab members:
 |
Fernando Lizcano, M.D.,
Ph.D. |
Raul Villanueva, M.D. |
Laboratory Focus:
Our lab investigates the effects of perturbation of complex transcriptional
pathways on neurodegeneration and cancer. Dr. Dangond cloned HDAC3 in
human and mouse. We work on characterizing the function of other transcriptional
regulators that are implicated in cell proliferation, survival and differentiation.
We also attempt gene replacement therapy in mice models of neurodegeneration
using adeno-associated virus as a vector. Finally, we utilize DNA microarray
technology to explore mechanisms that operate in autoimmunity, neurodegeneration
and cancer.
Current Funding:
NIH, Hope for ALS, Private Gifts
Selected Articles
| 1. | Dangond F, et al. | Differential Display Cloning of a Novel Human Histone Deacetylase (HDAC3) cDNA from PHA-Activated Immune Cells. | Biochem Biophys
Res Com 1998; 242: 648-52. |
| 2. | Dangond F, et al. | Differential Expression of Human Histone Deacetylase mRNAs in Response to Immune Cell Apoptosis Induction by Trichostatin A and Butyrate. | Biochem Biophys Res Com 1998;
247: 833-7. |
| 3. | Dangond F, et al. | Cloning and Expression of a Murine Histone Deacetylase 3 (mHdac3) cDNA and Mapping to a Region of Conserved Synteny between Murine Chromosome 18 and Human Chromosome 5. | Mol Cell Biol Res Com 1999;
2: 91-96. |
| 4. | Lizcano F, et al. | Cell Type-specific Roles of Histone Deacetylase in TR Ligand-independent Transcriptional Repression. | Mol Cell Endocrinol 2001; 172:
13-20. |
| 5. | Dangond F, et al. | Differential expression of Class I HDACs: roles of cell density and cell cycle. | Int J Oncol 2001;
19: 773-7. |
| 6. | Hsiao LL, et al. | A Compendium of Gene Expression in Normal Human Tissues. | Physiol Genomics 2001 Dec 21;7(2):97-104. |
| 7. | Dangond, F. | Chips around the world: proceedings from the
Nature Genetics microarray meeting. |
Physiol Genomics. 2000 Mar 13;2(2):53-8 |
| 8. | Gray SG et al. | Identification of a novel splice variant of class I histone deacetylase 3. | In preparation. |
Edited Books
| 1. | Dangond F, Editor. | Disorders of Myelin in the Central and Peripheral Nervous Systems. | Boston, Butterworth-Heinemann,
June 2002. |
Selected Book Chapters
1. |
Dangond F et al. | Neurogenetics. In: Toro GJ, Vallejo ME, editors. Treatise of Clinical Neurology [Tratado de Neurologia Clinica]. | Santa Fe de Bogota:
Lerner; 1994. p. 889-912. |
2. |
Mikati MA et al. | Autosomal Dominant Alternating Hemiplegia of Childhood. In: Andermann F, Aicardi J, Vigevano F, editors. Alternating Hemiplegia of Childhood. | International Review of Child
Neurology Series. New York: Raven Press, Ltd.; 1995. p. 125-43. |
3. |
Dangond F et al. | Immunology of HTLV-I Infection. In: Zaninovic V, editor. HTLV: Truths and Questions. | Cali: Feriva; 1996. p. 78-88. |
4. |
Dangond F. | Immunology of HAM/TSP. In: Zaninovic' V, de Castro-Costa CM, editors. HAM/TSP. Tropical Spastic Paraparesis or HTLV-I-associated Myelopathy. | Cali: Feriva; 1998. p. 80-90. |
5. |
Dangond F. | Amyotrophic Lateral Sclerosis. In: Sanders DB, editor. eMedicine Neurology. | Internet electronic publication,
2001. |
6. |
Dangond F. | Multiple Sclerosis. In: Sanders DB, editor. eMedicine Neurology. | Internet electronic publication,
2001. |
7. |
Sanchez E et al. | Infectious Diseases of the Nervous System [Enfermedades Infecciosas del Sistema Nervioso]. In: Toro GJ, Yepes MS, Palacios E, editors. | Neurology. McGraw Hill, 2001,
p. 177-220. |
8 |
Dangond F et al. | Immunologic and clinical aspects of human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis. In: Dangond F, ed. Disorders of Myelin in the Central and Peripheral Nervous Systems. | Butterworth-Heinemann, June
2002, p. 245-257. |
9. |
Dangond F et al. | HTLV-I-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). | Continuum Course on Neuroimmunology,
(7): 3; June 2001. |
10. |
Dangond F et al. | Human T-lymphotropic Viruses (HTLV). In: Daroff RB, Aminoff MJ, editors. Encyclopedia of the Neurological Sciences. | Academic Press, 2002 (In Press). |
11. |
Dangond F. | Multiple Sclerosis: A Prototypical Human Demyelinating Disease. In: Dangond F, ed. Disorders of Myelin in the Central and Peripheral Nervous Systems. | Butterworth-Heinemann, June
2002, p. 103-138. |
12. |
Smith D et al. | Disorders that mimic Multiple Sclerosis. In: Dangond F, ed. Disorders of Myelin in the Central and Peripheral Nervous Systems. | Butterworth-Heinemann, June
2002, p. 201-243. |
13. |
Dangond F. | From Genetics to Genomics and Proteomics. New Technologies in Myelin Research. In: Dangond F, ed. Disorders of Myelin in the Central and Peripheral Nervous Systems. | Butterworth-Heinemann, June
2002, p. 355-363. |
14. |
Dangond F. | Alternating Hemiplegia of Childhood. In: Gruson ES. Guide to Rare Disorders of the National Organization for Rare Diseases. | Lippincott 2001 (In Press). |
15. |
Sanin LC et al. | Metabolic Neuropathies. In: Sanders DB, editor. eMedicine Neurology. | Internet electronic publication,
2001. |
Selected Abstracts
1. |
Dangond F et al. | Role of Histone Deacetylase 3 (HDAC3) in Human Immune Cell Activation and Differentiation. | Experimental Biology
98, San Francisco, California, April 18-22, 1998. In: The FASEB
Journal 1998; 12 (4): A307. |
2. |
Dangond F et al. | Cloning and Chromosomal Mapping of Murine Histone Deacetylase 3. | Experimental Biology 99, Washington,
D.C., April 17-22, 1999. In: The FASEB Journal 1999; 13(4): A268.7 |
3. |
Dangond F et al. | Differential Gene Expression in Human Spinal Cord Tissues from ALS Patients. Nature Genetics | The Microarray Meeting September
22-25, 1999, Scottsdale, Arizona. In: Nature Genetics Electronic
Publication, November 1999. |
4. |
Gullans SR et al. | The Human Gene Expression (HuGE) Index: An Analysis of Gene Expression in Normal Human Tissues. | Cold Spring Harbor Laboratory
Meeting Abstract. 2000. |
5. |
Villanueva R et al. | Induction of HTLV-1 Tax and Immune Genes in Infected Cells by Histone Deacetylase Inhibition and DNA Demethylation Agents. | Experimental Biology April 3,
2001, Orlando, FL. |
6. |
Villanueva R et al. | Histone Deacetylation and DNA Demethylation as Key Regulatory Mechanisms in the Expression of Tax and Host Genes by HTLV-1 Infected Immune Cells. | International Congress on Human
Retrovirology, Dublin, Ireland, June, 2001. Abstract In: AIDS Res
Hum Retroviruses. (17): 1, p. S-55 (P-091), 2001. |
7. |
Dangond F et al. | Histone Deacetylation and DNA Methylation as Key Repressive Mechanisms for HTLV-1 Tax and Host Gene Transcription in Immune Cells. | XIth International Congress
of Immunology, Stockholm, Sweden, July, 2001. Abstract In: Scandinavian
Journal of Immunology. (54): 1, p. 109 (P-1222), July-August 2001. |
Selected Talks
| 1987 | Invited Lecture on First Neurological Cases of AIDS reported in Colombia, to Members of the Colombian Neurological Association and Members of the Editorial Board, Acta Medica Colombiana. Sponsored by Colombian Neurological Association |
| 1990 | Seminar on Multiple Sclerosis, Diabetes Mellitus Type I and other Diseases: a Role for the HLA system and the T Lymphocyte, to Members of the Scientific Staff, Eunice Kennedy Shriver Center, Waltham, MA. Invited by EKS Center |
| 1991 | Seminar on Acute Disseminated Encephalomyelitis and related Demyelinative Disorders, to members of the Neuropathology Department, Brigham and Women’s Hospital, Harvard Medical School. Neuropathology rotation |
| 1991 | Seminar on Progressive Multifocal Leukoencephalopathy, to members of the Neuropathology Department, Brigham and Women’s Hospital, Harvard Medical School. Neuropathology rotation |
| 1993 | Invited Lecture on Advances in the Treatment of Multiple Sclerosis,
U.S.-Colombian Medical Association Annual Meeting, July 27-31, Tampa, Florida. Invited by U.S.-Colombian Medical Association |
| 1993 | Invited Lecture on Recent Advances in Neuroimmunology, Fourth Annual Rheumatology Congress & Second International Rheumatology Symposium, Dec 4-6, Bogota, Colombia. Invited by Colombian Rheumatological Association |
| 1994 | Invited Lectures on Immunotherapy of Multiple Sclerosis and Neuroimmunology, XIII National Internal Medicine Congress, Medellin, Colombia, September. Invited by Colombian Medical Association |
| 1994 | Invited Lecture on Recent Advances in Autoimmunity, Massachusetts Institute of Technology (MIT), Boston, October. Sponsored by MIT Latin American Student Association |
| 1995 | Invited Lectures on Molecular Biology of Tropical Spastic Paraparesis, Molecular Biology of Demyelinating Diseases, Future Directions in Multiple Sclerosis, and Advances in the Treatment of Multiple Sclerosis, II National Neurology Congress, Barranquilla, Colombia, Nov 1-5. Invited by Colombian Neurological Association |
| 1995 | Invited Lecture on Multiple Sclerosis-Today and The Future, Baptist Hospital, Miami, sponsored by the National Multiple Sclerosis Society, Florida Chapter, Nov 29 |
| 1996 | Invited Lectures on Immunology of Tropical Spastic Paraparesis, New Concepts on Treatment of Demyelinating Diseases, and Recent Advances in Multiple Sclerosis, XVII Update in Medicine and Surgery Congress, sponsored by the Medical-Surgical Society of Atlantico, Barranquilla, Colombia, May 16-18 |
| 1996 | Identification of Costimulatory Molecules and Novel Activation Markers in Multiple Sclerosis; Howard Hughes Medical Institute Headquarters, Chevy Chase, Maryland, June 11 |
| 1996 | Invited Lecture on Immunology of Epilepsy; Hospital Militar Central, 25th Anniversary Neurology Department, Santa Fe de Bogota, Colombia, August 30. Sponsored by Hospital Militar Central Neurology Department |
| 1996 | Neurology Grand Rounds: Lecture on Identification of Costimulatory Molecules and Novel Activation (Histone Deacetylase) Markers from Multiple Sclerosis Immune Cells; New York University (NYU) Medical Center, New York, NY. Invited by the Department of Neurology, NYU, September 13 |
| 1997 | Invited Lectures on Advances in Tropical Spastic Paraparesis, and Acute Disseminated Encephalomyelitis, XV National Internal Medicine Congress, Santa Fe de Bogota, Colombia. Invited by the National Internal Medicine Association, October 12 |
| 1997 | Invited Lecture on Immunology of MS, I International Research Symposium on MS, Puebla, Mexico. Invited by the Mexican Association of Neurology, June 26 |
| 1997 | Invited Lecture on Transmissible Diseases of the Central Nervous System, III National Neurology Congress, Medellin, Colombia. Invited by the Colombian Neurological Association, August 18 |
| 1998 | Invited Lecture on Immune Mechanisms of Demyelinating Disease, XXI National Neurology Congress, Mazatlan, Mexico. Invited by the Mexican Association of Neurology, November 3 |
| 1998 | Seminar on Mechanisms of Demyelinating and Inflammatory Central Nervous System Diseases, Harvard Institutes of Medicine, Boston, MA. Invited by Partners Neurology residents, October 13 |
| 1999 | Invited Lecture on Role of Global Transcriptional Repressors in Psychoneuroimmunology, III PanAmerican Congress of Neuropsychopharmacology, Bogota, Colombia, February 18 |
| 1999 | Invited Lecture on Molecular Perspectives for Psychoneuroimmunology in the Next Millennium, III PanAmerican Congress of Neuropsychopharmacology, Bogota, Colombia, February 18 |
| 1999 | Invited Lecture on Functional Genomics of Demyelinating Diseases, Xth PanAmerican Congress of Neurology, Cartagena de Indias, Colombia, October 14 |
| 1999 | Clinical Case Presentation and Discussion, Demyelination Cases, Xth PanAmerican Congress of Neurology, Cartagena de Indias, Colombia, October 14 |
| 2000 | Invited Lectures on Multiple Sclerosis and on Genomics of Central Nervous System Degeneration, IV PanAmerican Congress of Neuropsychopharmacology, Bogota, Colombia, February 24 |
| 2000 | Invited Lecture on Genes and Disease in Neurology, U.S.-Colombian Medical Association Annual Meeting, Washington, D.C., July 6 |
| 2000 | Lecture on Gene Expression Profile of the Human ALS Spinal Cord. Annual Young Investigator Workshop of the Amyotrophic Lateral Sclerosis Association (ALSA). Philadelphia, PA, October 26 |
| 2001 | Histone Deacetylation and DNA Demethylation as Key Regulatory Mechanisms in the Expression of Tax and Host Genes by HTLV-1 Infected Immune Cells. International Congress on Human Retrovirology, Molecular Biology Workshop Presentation, Dublin, Ireland, June, 2001. |
| 2001 | Lecture on Diagnosis and Therapy of Multiple Sclerosis. Spaulding Rehabilitation Hospital, Boston MA, September 25 |
| 2001 | Lecture on Future Directions in Multiple Sclerosis. XI Annual Intensive Review of Neurology Course. Harvard Medical School. Department of Continuing Education, Boston MA, October 8 |
| 2002 | Neurodegeneration and Autoimmunity: Effects of Perturbations of Complex Transcriptional Pathways. Harvard Institutes of Medicine, Boston, MA, June 14, 2002 |